Research paper
A Proper Enteral Nutrition Support Improves Sequential Organ Failure Score and Decreases Length of Stay in Hospital in Burned Patients
Study answer
What this study found
Early, adequate enteral nutrition with ENTERA Meal significantly improved organ-function scores by day 9 (SOFA3 lower than SOFA1 in the intervention group; between-group SOFA3 vs SOFA0 difference significant, P=0.039). Length of hospital stay tended to be shorter in the intervention group (17.6±8.2 vs 23.1±11.9 days) but this was not statistically significant (P=0.375). Adequate early nutrition reduced hypermetabolic stress and may decrease LOS and costs in burn care.
- Study & population
- Design: double-blind randomized controlled clinical trial, conducted at Sina Burn Center, Tabriz University of Medical Sciences, Iran.
- Intervention
- Enteral nutrition with ENTERA Meal (1 kcal/mL; 54.6% carbohydrate, 14% protein, 31.6% fat); started within 1 hour of ICU admission; initial rate 25 mL/h, titrated to meet calculated energy requirements within 3 days; energy target based on Harris-Benedict formula × 1.5; protein target 1.5–2 g/kg/day for TBSA >30%.
- Key limitation
- Small, single-center trial (n=30); short follow-up (9 days); some dropouts; limited generalizability across burn severities and settings.
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Open PDFOriginal abstract
Background: Severe burned patients developed metabolic imbalances and systemic inflammatory response syndrome (SIRS), which can lead to malnutrition, impaired immunologic response, multiple organ failure and death. Studies have shown that providing a…