A Meta-Analysis of the Impact of Resveratrol Supplementation on Markers of Renal Function and Blood Pressure in Type 2 Diabetic Patients on Hypoglycemic Therapy

Study answer

What this study found

Resveratrol produced a clear reduction in systolic blood pressure, but glycemic and renal effects were inconsistent overall. Pooled effects were not significant for fasting glucose (SMD = -0.06, 95% CI: -0.24, 0.12), insulin (SMD = -0.08, 95% CI: -0.50, 0.34), or HbA1c (SMD = 0.18, 95% CI: -0.17, 0.52), and renal markers were mostly null, including creatinine (SMD = 0.13, 95% CI: -0.15, 0.40) and uric acid (SMD = -0.25, 95% CI: -0.56, 0.06). Systolic blood pressure decreased significantly (SMD = -5.77, 95% CI: -8.61, -2.93; p = 0.02), while total protein showed a small decrease (SMD = -0.19,…

Study & population

This was a meta-analysis of five studies including 388 adults with type 2 diabetes receiving hypoglycemic therapy, mainly metformin-based regimens.

Intervention

Oral resveratrol supplementation was tested across five trials in varying doses and durations.

Key limitation

The evidence base was small, with only five trials and heterogeneous dosing regimens and durations.

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Original abstract